Check out our free Chiefs vs Panthers pick and preview for this NFL week 12 game in Charlotte. See who we like to win and cover the spread in this week 12 regular season matchup.
The Panthers, sitting at +440 on the money line, are heavy underdogs as they host the Chiefs at 1:00 ET on Sunday, November 24th at Bank of America Stadium in Charlotte, NC. The Chiefs are favored by -11 on the road, with the over/under line set at 41.5 points. This non-conference matchup is being televised on CBS.
Chiefs vs. Panthers Matchup At A Glance
- Sport: NFL
- Teams: Kansas City Chiefs at Carolina Panthers
- Where: Charlotte at Bank of America Stadium
- Date: Sunday, November 24th
- Betting Odds KC -11, KC -607 | CAR +440 O/U 41.5

Chiefs Preview:
Heading into week 12, the Chiefs sit at 9-1, putting them 1st in the AFC West and our NFL power rankings. We give Kansas City a 93.3% chance of winning the division and a 100% chance of making the playoffs. After nine straight wins to start the season, the Chiefs suffered their first loss in week 11, falling 30-21 on the road against the Bills. They were 3-point underdogs in that game but couldn’t cover the spread, snapping their four-game ATS losing streak.
So far, the Chiefs are 4-5-1 against the spread, with an average scoring margin of +4.9 points per game. Their O/U record is 5-5, with their games averaging 43.1 points (the O/U line has been 45 on average).
Chiefs Offense Breakdown
Patrick Mahomes threw for 196 yards and 3 touchdowns in week 11, completing 23 of 33 passes, but he also had 2 interceptions. Kareem Hunt had 60 rushing yards on 14 carries, and Xavier Worthy led the team with 4 catches for 61 yards and a touchdown. Kansas City scored 7 points in the 4th quarter after being shut out in the 1st and 3rd quarters. They converted 5 of 10 third downs and scored on all 3 red zone trips.
Heading into week 12, the Chiefs rank 9th in our offensive power rankings. They lead the NFL in 3rd-down conversions, with a 51.9% success rate, and are 10th in passing yards per game (226.5) and points per game (24). However, they rank 23rd in rushing yards per game and 25th in 1st-quarter scoring.
Chiefs Team Defense
In their 30-21 loss to the Bills, the Chiefs' defense allowed Buffalo to convert on 60% of their third down attempts. The Chiefs gave up 262 passing yards, with Josh Allen completing 67.5% of his passes against them. They also allowed 104 rushing yards on 31 attempts.
Despite coming up with one interception, the Chiefs were unable to generate much pressure, finishing with no sacks and losing the quarterback hit battle by a margin of -3. Buffalo finished with 366 total yards in the game.Panthers Preview:
After snapping a six-game losing streak with back-to-back wins, the Panthers sit at 3-7 heading into week 12. Carolina followed up their week 9 win over the Saints with a 20-17 victory over the Giants in week 10, narrowly covering the 6.5-point spread. The O/U line was 40 points, and the teams combined for 37. The Panthers are now 7-3 on O/Us this season.
Despite their two-game winning streak, the Panthers rank 30th in our NFL power rankings and have just a 0.3% chance of making the playoffs. They are 4th in the NFC South with a 1-2 division record. Against the spread, Carolina is 3-7, with all of their games coming as underdogs.
Panthers Offense Breakdown
Carolina ranks 29th in our offensive power rankings, averaging 16.7 points per game (27th in the NFL). They are 32nd in the league in total offense, with 280.7 yards per game. The Panthers are 15th in passing attempts but 29th in passing yards, averaging 170.7 per game. On the ground, they rank 24th in both rushing attempts and yards, with 110 per game. Carolina has struggled on 3rd down, converting 33.3% of their attempts (27th in the NFL), but they are 8th in red zone conversion percentage.
Bryce Young has improved his passer rating in each of the last three games, posting an 86.0 rating in week 10 against the Giants. He threw for 126 yards and a touchdown on 15/25 passing in that game. Chuba Hubbard led the rushing attack with 153 yards on 28 carries, while Jalen Coker had 3 catches for 41 yards.
Panthers Team Defense
In their 20-17 overtime win over the Giants, the Panthers' defense gave up 342 yards, but they played well in the passing game, allowing just 175 yards through the air. They struggled against the run, giving up 167 yards on 34 attempts. Despite this, the Panthers didn't allow a single touchdown through the air and came away with two interceptions.
The Panthers held the Giants to a 59.5% completion rate and limited them to a 4.7 yards per attempt in the passing game. On third downs, the Giants converted 46.7% of their chances. Carolina's defense also managed two sacks in the game.Chiefs vs Panthers Betting Odds, Trends & Analysis
- Across the Chiefs last three road games, the team averaged 25 points per game while allowing 22. Their record vs the spread in these contests was 1-2, while going 2-1 straight-up.
- Across their ten previous home games, Carolina has an ATS mark of 2-7-1. Their straight up record in these matchups was 1-9 while averaging 12 points per game.
- Going back to their previous ten games as the underdog, Carolina has an ATS mark of 3-7 while going 3-7 straight up.
- Through their previous five contests as the betting favorite, the Chiefs have a strong record of 5-0. Their record vs the spread in these matchups is 1-3-1.
Chiefs vs Panthers Free Pick
- KnupSports.com Free Betting Pick: Chiefs -11 Be sure to check out our other NFL Football betting previews for this week. KnupSports.com also updates their sports betting picks page daily with plays across all sports.