Buffalo Bills vs San Francisco 49ers Matchup

In this week 13 NFL regular season preview between 49ers and Bills, see who like to win the game and cover the spread.

The 49ers and Bills will face off on Sunday, December 1st at 8:20 ET on NBC. The Bills are the heavy favorite with a point spread of -7 and money line odds of -319. This week 13 non-conference matchup is being played at Highmark Stadium in Orchard Park, NY, and the over/under line is set at 45.5 points. The 49ers' record is missing, but Buffalo comes in with a record of ________.

49ers vs. Bills Matchup At A Glance

Sport: NFL
Teams: San Francisco 49ers at Buffalo Bills
Where: Orchard Park at Highmark Stadium
Date: Sunday, December 1st
Betting Odds BUF -7, SF +252 | BUF -319 O/U 45.5

49ers Preview:

After a week 10 win over the Buccaneers, the 49ers have dropped two straight, including a 38-10 loss to the Packers in week 12. San Francisco was unable to cover the 6.5-point spread as underdogs, leaving them 4-7 ATS this season. They rank 7th in our NFL power rankings but have just a 16.4% chance of making the playoffs.

San Francisco is 5-6 on the year and sits 4th in the NFC West. In division games, they are 1-3, and they have a 3-5 record in conference play. The 49ers are 3-3 at home and 2-3 on the road.

49ers Offense Breakdown

San Francisco heads into week 13 ranked 12th in our offensive power rankings. They are 13th in the NFL in scoring, averaging 23.6 points per game, and 4th in passing yards, with 246.2 per game, despite ranking 20th in passing attempts. The 49ers are 7th in rushing yards, averaging 138.4 per game, on 28.5 attempts per game. They have struggled in the red zone, ranking 21st in conversion percentage, but are 6th in the league in 3rd-down conversions.

In week 12, the 49ers managed just 10 points in a loss to the Packers, with all of their scoring coming in the 2nd and 3rd quarters. Brandon Allen threw for 197 yards, going 17/29, with 1 touchdown and 1 interception. Christian McCaffrey had 31 yards on 11 carries, and George Kittle led the team with 6 catches for 82 yards.

49ers Team Defense

In their 38-10 loss to the Packers, the 49ers' defense allowed 325 total yards. They struggled against the run, giving up 169 yards on 42 attempts, but were better against the pass, allowing just 156 yards on 13 completions. Despite this, the Packers still managed to score two passing touchdowns.

On 3rd downs, the 49ers allowed the Packers to convert 46.2% of their chances. San Francisco's defense did manage to come up with two sacks in the game.

Bills Preview:

With six straight wins, the Bills have a 9-2 record and a 100% chance of winning the AFC East, according to our projections. After two consecutive road wins, Buffalo returned home in week 11 to beat the Chiefs 30-21. They were favored by 3 points and covered the spread, bringing their ATS record to 7-4. The over hit for the third straight game, with the teams combining for 51 points.

Buffalo ranks 3rd in our NFL power rankings and is 2nd in the AFC standings. They are 5-0 at home and 4-2 on the road. Their average scoring margin this season is +9.6 points per game.

Bills Offense Breakdown

Josh Allen threw for 262 yards and a touchdown in week 11, completing 27 of 40 passes against the Chiefs, with one interception. He also led the team in rushing with 55 yards on 12 carries. Khalil Shakir was his top target, catching 8 passes for 70 yards. The Bills' offense scored 14 points in the 4th quarter and converted 9 of 15 third downs, while going 3/4 in the red zone.

Buffalo ranks 3rd in the NFL in points per game, averaging 29.1. They are 13th in passing yards per game (226.1) and rushing yards per game (119.2). Despite being 2nd in red zone attempts, they rank 28th in red zone conversion percentage, with a 6.4% success rate.

Bills Team Defense

In their 30-21 win over the Chiefs, the Bills' defense allowed just 78 rushing yards on 17 attempts and held Kansas City to 259 total yards. Despite giving up three passing touchdowns, Buffalo defended well against the pass, allowing just 181 yards through the air. They also came away with two interceptions.

The Bills' defense did struggle to get off the field, as the Chiefs converted on 50% of their third down attempts. However, Buffalo's two sacks and three more quarterback hits were key in disrupting the Chiefs' passing game.

49ers vs Bills Betting Odds, Trends & Analysis

Across the 49ers last five road games, the team averaged 22 points per game while allowing 26. Their record vs the spread in these contests was 1-4, while going 2-3 straight-up.
Across their last three home contests, Buffalo has been good against the spread posting a mark of 3-0. Their overall mark in these games was 3-0, while averaging 28 points per game.
Going back to their last three games as the underdog, the 49ers have a straight up record of 1-2. But, their mark vs the spread was just 1-2.
Spanning across their last ten games as the betting favorite, the Bills have gone 7-3 vs the spread. Their overall record in these games was 9-1.