Check out our free Bills vs Lions pick and preview for this NFL week 15 game in Detroit. See who we like to win and cover the spread in this week 15 regular season matchup.
The Lions are favored at -1.5 as they host the Bills at 4:25 ET on Sunday, December 15th at Ford Field in Detroit. The Lions' money line odds are -129, and the game is being televised on CBS. Buffalo's money line odds are +107, and the over/under line is set at 55 points. This non-conference matchup is week 15 for both teams.
Bills vs. Lions Matchup At A Glance
- Sport: NFL
- Teams: Buffalo Bills at Detroit Lions
- Where: Detroit at Ford Field
- Date: Sunday, December 15th
- Betting Odds DET -1.5, BUF +107 | DET -129 O/U 55

Bills Preview:
At 10-3, the Bills sit atop the AFC East and rank 2nd in our NFL power rankings. Our projections give them a 100% chance of making the playoffs and winning their division. Buffalo is 6-0 at home this season but just 4-3 on the road, including a 44-42 loss to the Rams in week 14. The Bills were 3.5-point favorites in that game but couldn’t hold on for the win.
Buffalo is 8-5 against the spread this season, with an average scoring margin of +9.9 points per game. They are 7-3 ATS as favorites and 1-2 as underdogs. Their O/U record is 8-5, with their games averaging 51.2 points compared to an average line of 46.3.
Bills Offense Breakdown
Josh Allen has been on fire for the Bills, posting a passer rating of 117 in week 14, with 342 yards and 3 touchdowns against the Rams. He also rushed for 82 yards and 3 touchdowns. Buffalo's offense came alive in the 4th quarter, scoring 21 points, and they converted 3 out of 3 red zone attempts.
Heading into week 15, the Bills rank 2nd in our offensive power rankings. They are 2nd in the NFL in points per game (30.5) and 10th in yards per game (355). Despite being 20th in passing attempts, they rank 12th in passing yards per game (229.3).
Bills Team Defense
In their 44-42 loss to the Rams, the Bills' defense struggled to get off the field, allowing the Rams to convert on 73.3% of their third down attempts. Buffalo gave up 320 passing yards on 23 completions, with the Rams averaging 10.7 yards per attempt through the air. Overall, Buffalo allowed 457 total yards and 137 rushing yards on 42 attempts.
The Bills' defense couldn't generate much pressure, failing to record a sack in the game. Despite this, they did manage to outperform the Rams in both QB hits and tackles for loss.Lions Preview:
With their 34-31 win over the Packers in week 14, the Lions extended their winning streak to 11 games, bringing their record to 12-1. Detroit currently holds the top spot in our NFL power rankings and has a 100% chance of making the playoffs, along with an 89% chance of winning the NFC North. They are 4-0 in division games and 8-1 in conference play.
Detroit is 9-3-1 against the spread this season, with an average scoring margin of +14.1 points per game. Their O/U record is 6-6-1, with their games averaging 50.1 points. The O/U line for their week 14 matchup with Green Bay was 53 points, and the teams combined for 65.
Lions Offense Breakdown
Jared Goff has been on a roll for the Lions, posting a passer rating of 109 in week 14 against the Packers, with 283 yards and 3 touchdowns on 32/41 passing. He threw for 221 yards in week 13 and 269 yards in week 12. Goff has also been well-protected, with only 2 sacks in his last two games. Jameson Williams led the team with 80 receiving yards in week 14, while David Montgomery rushed for 51 yards and a touchdown.
Detroit's offense ranks 3rd in our power rankings and leads the NFL in scoring, averaging 32.1 points per game. They are 2nd in total yards per game (394.8) and 4th in passing yards per game (243.8), despite ranking 22nd in passing attempts. On the ground, they are 4th in rushing yards per game, with 151.1, on 32.5 attempts per game.
Lions Team Defense
The Lions' defense played well on third downs in their 34-31 win over the Packers, allowing just a 20% conversion rate. They held Green Bay to 199 passing yards on 12 completions and limited them to 1 touchdown through the air. Detroit's defense also defended the run decently, giving up 99 yards on 24 attempts.
Although they only had one sack, the Lions' defense did manage to hit the quarterback four more times than Green Bay. Additionally, the Lions' defense forced the Packers to throw the ball downfield, as Green Bay averaged 10 yards per attempt.
Bills vs Lions Betting Odds, Trends & Analysis
- Across their last three road contests, Buffalo has been good against the spread posting a mark of 2-1. Their overall mark in these games was 2-1, while averaging 34 points per game.
- When looking at their past five home matchups, Detroit has an ATS record of 4-1 while averaging 30 per game. The team went 5-0 overall in these games.
- Going back to their last ten games as the underdog, the Bills have a straight up record of 4-6. But, their mark vs the spread was just 4-6.
- In their last ten games as the betting favorite, the Lions have a straight up record of 10-0 and an ATS mark of 7-2-1.
Bills vs Lions Free Pick
- KnupSports.com Free Betting Pick: Bills +1.5 Be sure to check out our other NFL Football betting previews for this week. KnupSports.com also updates their sports betting picks page daily with plays across all sports.