Clemson Tigers vs Louisville Cardinals Matchup

Check out our free Louisville Cardinals vs Clemson Tigers pick and preview for this CFB week 10 game in Clemson. See who we like to win and cover the spread in this week 10 CFB matchup.

Memorial Stadium in Clemson, SC, is the site for this week 10 matchup between the Louisville Cardinals and Clemson Tigers. The game is set for 7:30 ET, and ESPN will be handling the broadcast. Clemson is the -10.5 point favorite, with the over/under line at 61.5 points. The Tigers are 6-1 on the season, while Louisville comes in with a 5-3 record.

Cardinals vs. Tigers Matchup At A Glance

  • Sport: CFB
  • Teams: Louisville Cardinals at Clemson Tigers
  • Where: Clemson at Memorial Stadium (Clemson, SC)
  • Date: Saturday, November 2nd
  • Betting Odds CLMSN -10.5, LOU +313 | CLMSN -406 O/U 61.5

Cardinals Preview:

Louisville heads into Week 10 against Clemson with a 5-3 record, ranked 17th in our power rankings. They have a 98.9% chance of becoming bowl-eligible but only a 0.1% chance of winning the Atlantic Coast. So far, they are 2-2 at home and 2-1 on the road this season.

The Cardinals have been favored in five of their eight games, going 4-1 as the favorite. Their average scoring margin is +12 points, but they are 2-5 against the spread, including an 0-3 mark on the road.

This week’s over/under line is 61.5 points, higher than their average line of 54.5. Louisville’s over/under record is 5-2, with their games averaging 61.2 points per contest.

Cardinals Offense Breakdown

Louisville’s offense is averaging 36.6 points per game, placing them 17th in the nation, and they are ranked 16th in our offensive power rankings heading into week 10. Their passing game has been their strength, averaging 302.8 yards per game, which ranks 10th nationally. They are 12th in completions, with 23.2 per game, and 21st in passing attempts, averaging 35.5 per game.

Tyler Shough has thrown for 2,348 yards and 20 touchdowns, with five interceptions, and he has a passer rating of 108. Louisville ranks 19th in passer rating nationally. Isaac Brown leads the rushing attack with 649 yards, averaging 7 yards per carry. Ja’Corey Brooks has 799 receiving yards and eight touchdowns on 44 catches.

Cardinals Team Defense

Louisville's defense will look to improve after allowing three passing touchdowns in their last game against Boston College, although they did give up just 164 passing yards and 154 rushing yards. Overall, they allowed 318 total yards and 14 first downs in the game.

On the season, Louisville is giving up 24.6 points per game, ranking 56th nationally. Opponents are averaging 222.8 passing yards per game and 137.5 rushing yards against the Cardinals. Quarterbacks have completed 63.5% of their passes and have a passer rating of 98.1 against Louisville’s defense.

Tigers Preview:

Louisville heads into Week 10 against Clemson with a 5-3 record, ranked 17th in our power rankings. They have a 98.9% chance of becoming bowl-eligible but only a 0.1% chance of winning the Atlantic Coast. So far, they are 2-2 at home and 2-1 on the road this season.

The Cardinals have been favored in five of their eight games, going 4-1 as the favorite. Their average scoring margin is +12 points, but they are 2-5 against the spread, including an 0-3 mark on the road.

This week’s over/under line is 61.5 points, higher than their average line of 54.5. Louisville’s over/under record is 5-2, with their games averaging 61.2 points per contest.

Tigers Offense Breakdown

Clemson’s offense ranks 4th in our offensive power rankings and in points per game, averaging 42 as they head into week 10 against Louisville. Quarterback Cade Klubnik has thrown for 1,836 yards, completing 66.7% of his passes, and has 20 touchdowns with just three interceptions, giving him a passer rating of 117.

Clemson ranks 38th in passing yards per game, averaging 290.6, and 43rd in rushing with 201 yards per game. Phil Mafah leads the ground game with 692 rushing yards, averaging 6 yards per carry, and has scored six touchdowns. Antonio Williams is the top receiver, with 393 yards and five touchdowns.

Tigers Team Defense

Heading into their matchup with Louisville, Clemson's defense is ranked 31st nationally, allowing 23 points per game. They’ve given up 218 passing yards per game, ranking 86th, and 133 rushing yards per game. Opposing quarterbacks have completed 56% of their passes, with a passer rating of 81.7 against Clemson’s defense.

In their recent game against Virginia, Clemson’s defense allowed 31 points but limited the Cavaliers to just 18 rushing yards on 28 attempts. Virginia threw the ball 41 times, completing 24 passes for 281 yards, while Clemson’s defense also recorded two interceptions.

Cardinals vs Tigers Betting Odds, Trends & Analysis

  • When looking at their past five road matchups, Louisville has an ATS record of 0-5 while averaging 22 per game. The team went 2-3 overall in these games.
  • Through their last ten home games, Clemson has an ATS record of just 4-6. However, their overall record was 6-4 while averaging 24 points per game.
  • In their last five games as the betting underdog, the Louisville Cardinals have a straight up record of 1-4 and an ATS mark of 1-4.
  • Going back to their previous ten games as the favorite, Clemson has an ATS mark of 7-3 while going 10-0 straight up.

Louisville Cardinals vs Clemson Tigers Free Pick

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